Genomic Structural Variants Lead to New DNA Scaffold and Fusion RNA in Aggressive Uveal Melanoma Models

David Gentien, Manager of the Genomics Platform, Curie Institute, Paris presents his study with OGM of uveal melanoma, a cancer of the eye that can be very aggressive once it metastasizes. Using Saphyr, he identified different types of structural variants that created several gene fusions believed to define this tumor type and that were missed by whole genome sequence and other molecular methods.