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Evolutionary and biomedical insights from a marmoset diploid genome assembly
Towards complete and error-free genome assemblies of all vertebrate species
Application of Full Genome Analysis to Diagnose Rare Monogenic Disorders
Optical maps refine the bread wheat Triticum aestivum cv Chinese Spring genome assembly
Live Webinar – Ravindra Kolhe, MD, PhD
Host genome analysis of structural variations by Optical Genome Mapping in patients with severe COVID-19
Ravindra Kolhe, MD, PhD
Department of Pathology, Section of Anatomic Pathology
Vice Chairman for Translation Research
Chief, Section of Molecular and Genetic Pathology
Augusta University
The varied clinical manifestations and outcomes in patients with SARS-CoV-2 infections implicate a role of host-genetics in the predisposition to disease severity. This role is supported by evidence that is now emerging, where initial reports identify common risk factors and rare genetic variants associated with high risk for severe/life-threatening COVID-19. We investigated the host genomes of individuals with severe/life-threatening COVID-19 at the structural variant level (500 bp – Mbps) to identify events that might provide insight into the inter-individual variability in clinical course and outcomes associated with SARS-CoV-2 infections and COVID-19 mortality.
