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The genetic architecture of phenotypic diversity in the betta fish (Betta splendens)

BioRxiv 2021
Zhang W. et al

The Betta fish displays a remarkable variety of phenotypes selected during domestication. However, the genetic basis underlying these traits remain largely unexplored. Here, we report a high-quality genome assembly and re-sequencing of 727 individuals representing diverse morphologies of the betta fish. We show that current breeds have a complex domestication history with extensive introgression with wild species. Using GWAS, we identify the genetic basis of multiple traits, including several coloration phenotypes, sex-determination which we map to DMRT1, and the long-fin phenotype which maps to KCNJ15. We identify a polygenic signal related to aggression with many similarities to human psychiatric traits, involving genes such as CACNB2 and DISC1. Our study provides a resource for developing the Betta fish as a genetic model for morphology and behavior in vertebrates.


Wanchang ZhangHongru WangDébora Y. C. BrandtBeijuan HuJunqing ShengMengnan WangHaijiang LuoShujie GuoBin ShengQi ZengKou PengDaxian ZhaoShaoqing JianDi WuJunhua WangJoep H. M. van EschWentian ShiJun RenRasmus NielsenYijiang Hong


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