• Home/
  • Evaluation of optical genome mapping for detecting chromosomal translocation in clinical cytogenetics

Evaluation of optical genome mapping for detecting chromosomal translocation in clinical cytogenetics

Molecular Genetics and Genomic Medicine 2022
Dai P, et al

Peng Dai, Xiaofan Zhu, Yanzheng Pei, Peng Chen, Jingjing Li, Zhi Gao, Yu Liang, Xiangdong Kong.

Balanced reciprocal translocation is one of the most common chromosomal abnormalities in humans that may lead to infertility, recurrent pregnancy loss, or having children with physical or mental abnormalities. Karyotyping and FISH are traditional detection approaches with a low resolution. Bionano optical genome mapping (OGM) developed in recent years can be used to analyze chromosomal abnormalities at a higher resolution, providing the possibility of more in-depth analyses of balanced chromosome translocations.

Top

This website stores cookies on your computer. These cookies are used to collect information about how you interact with our website and allow us to remember you. We use this information in order to improve and customize your browsing experience and for analytics and metrics about our visitors both on this website and other media. To find out more about the cookies we use, see our Privacy Policy.