• Application

  • Implementation

Publications

CRISPR-bind: a simple, custom CRISPR/dCas9-mediated labeling of genomic DNA for mapping in nanochannel arrays
bioRxIV 2018
Zhang D et al
Multi-platform discovery of haplotype-resolved structural variation in human genomes
bioRxiv 2018
Chaisson MJP et al
High-resolution comparative analysis of great ape genomes
Science 2018
Kronenber ZN et al
New technologies to uncover the molecular basis of disorders of sex development
Molecular and Cellular Endocrinology 2018
Barseghyan H et al
Optical mapping reveals a higher level of genomic architecture of chained fusions in cancer
Genome Research 2018
Eva KF Chan et al.
Single-molecule optical mapping enables accurate molecular diagnosis of facioscapulohumeral muscular dystrophy (FSHD)
BioRxIV 2018
Yi Dai et al
Reproducible integration of multiple sequencing datasets to form high-confidence SNP, indel, and reference calls for five human genome reference materials
BioRxIV 2018
Justin Zook et al
De novo assembly of two Swedish genomes reveals missing segments from the human GRCh38 reference and improves variant calling of population-scale sequencing data
BioRxIV 2018
Adam Ameur et al
Next-generation mapping: a novel approach for detection of pathogenic structural variants with a potential utility in clinical diagnosis
Genome Medicine 2017
Barseghyan H et al.
High-throughput single-molecule telomere characterization
Genome Research 2017
McCaffrey J et al
An Integrative Framework For Detecting Structural Variations In Cancer Genomes
BioRxiv 2017
Dixon J et al
Next Generation Mapping Reveals Novel Large Genomic Rearrangements in Prostate Cancer
Oncotarget 2017
Jaratlerdsiri W et al
Ongoing human chromosome end extension driven by a primate ancestral genomic region revealed by analysis of Bionano genomics data
BioRxIV 2017
Shao H et al
Rapid Automated Large Structural Variation Detection in a Diploid Genome by NanoChannel Based Next-Generation Mapping
BioRxIV 2017
Hastie A et al
De novo assembly and phasing of a Korean human genome
Nature 2016
Jeong-Sun Seo
Long-read sequencing and de novo assembly of a Chinese genome
Nature Communications 2016
Shi et al
Extensive sequencing of seven human genomes to characterize benchmark reference materials
Scientific Data (2016) 
Zook et al
Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays
Genetics 2016
Mak AC et al.,
Single Haplotype Assembly of the Human Genome from a Hydatidiform Mole.
Genome Research (2014); 24: 2066-2076 
Steinberg, K. et al.
Rapid Detection of Structural Variation in a Human Genome using Nanochannel-based Genome Mapping Technology.
Giga Science 2014
Cao, H., et al.
Finished Sequence and Assembly of the DUF1220-rich 1q21 Region Using a Haploid Human Genome.
BioMed Central Genomics (2014); 15(July 2014): 387 
O’Bleness, M., et al.
Genome mapping on Nanochannel arrays for structural variation analysis and sequence assembly.
Nature Biotechnology (2012); 30(8):771 
Lam, E.T., et al.

Videos

Bionano Genomics
Amy Files
University of California San Francisco, USA
Dr. Kwok discusses Bionano structural variant discovery in human diseases
Institute of Experimental Biology, Czech Republic
Dr. Jaroslav Dolezel discusses his work in plant genetics
Brigham Young University,
USA
Dr. Udall discusses Bionano mapping and the cotton genome
Kansas State University,
USA
Dr. Brown shares how Bionano genome maps help validate assemblies
Garvan Institute for Medical Research, Australia
Dr. Hayes discusses how Bionano aids her work prostate cancer

Webinars

Bionano Saphyr Access
Bionano Genomics
Bionano Access for Saphyr Genome Mapping
Bionano Genomics
Vanessa Hayes
Garvan Institute of Medical Research
Dr. Vanessa Hayes, PhD
Eric Vilain
Chief of Medical Genetics at UCLA
Dr. Eric Vilain, MD, PhD
Alex Harkess
Donald Danforth Plant Science Center
Alex Harkess
Florian Jupe
Salk Institute of Biological Studies
Florian Jupe
Wellcome Trust Sanger Institute
William Chow
Kansas State University
Dr. Sue Brown
Wageningen University
Dr. Gabino Sanchez Perez
Icahn School of Medicine at Mount Sinai
Dr. Ali Bashir and Dr. Bobby Sebra
The Genome Institute at Washington University
Tina Graves
Institute of Experimental Botany, Olomouc
Dr. Jaroslav Dolezel
Emory University
Dr. Michael Rossi

Posters

February, 2018
Advances in Genome Biology and Technology, Orlando, Fl
February, 2018
Advances in Genome Biology and Technology, Orlando, Fl
May, 2017
European Society of Human Genetics Annual Meeting, Copenhagen, Denmark
May, 2017
European Society of Human Genetics Annual Meeting, Copenhagen, Denmark
March, 2017
ACMG Annual Clinical Genetics Meeting, Phoenix, Arizona
February, 2017
Advances in Genome Biology and Technology 2017 General Meeting, Hollywood, FL
February, 2017
Advances in Genome Biology and Technology 2017 General Meeting, Hollywood, FL
January, 2017
Plant and Animal Genome Conference XXV, San Diego, CA
January, 2017
Plant and Animal Genome Conference XXV, San Diego, CA
October, 2016
American Society of Human Genetics, San Diego, CA
March, 2016
Annual Clinical Genetics Meeting, Tampa, FL
February, 2016
Advances in Genome Biology and Technology, Orlando, FL
February, 2016
Advances in Genome Biology and Technology, Orlando, FL
January, 2016
Plant and Animal Genome Conference XVII, San Diego, CA
January, 2016
Plant and Animal Genome Conference XVII, San Diego, CA
January, 2016
Plant and Animal Genome Conference XVII, San Diego, CA
January, 2016
Plant and Animal Genome Conference XVII, San Diego, CA
January, 2016
Plant and Animal Genome Conference XVII, San Diego, CA
October, 2015
American Society of Human Genetics, Baltimore, MD
October, 2015
American Society of Human Genetics, Baltimore, MD
October, 2015
American Society of Human Genetics, Baltimore, MD
October, 2015
American Society of Human Genetics, Baltimore, MD
October, 2015
American Society of Human Genetics, Baltimore, MD
May 2015 / June 2015
Biology of Genomes / European Society of Human Genetics, Cold Spring Harbor, NY (USA) / Glasgow (UK)
May 2015 / June 2015
Biology of Genomes / European Society of Human Genetics, Cold Spring Harbor, NY (USA) / Glasgow (UK)
May 2015 / June 2015
Biology of Genomes / European Society of Human Genetics, Cold Spring Harbor, NY (USA) / Glasgow (UK)
April 2015 / June 2015
American Association for Cancer Research / European Society of Human Genetics, Philadelphia, PA (USA) / Glasgow (UK)
February, 2015
Advances in Genome Biology and Technology, Marco Island, FL
February, 2015
Advances in Genome Biology and Technology, Marco Island, FL
February, 2015
Advances in Genome Biology and Technology, Marco Island, FL
January, 2015
Plant and Animal Genome XXIII, San Diego, CA
January, 2015
Plant and Animal Genome XXIII, San Diego, CA
January, 2015
Plant and Animal Genome XXIII, San Diego, CA
November, 2014
Precision Medicine: Personal Genomes & Pharmacogenomics, Cold Spring Harbor, NY
October, 2014
Beyond the Genome, Boston, MA
October, 2014
American Society of Human Genetics, San Diego, CA
October, 2014
American Society of Human Genetics, San Diego, CA
October, 2014
American Society of Human Genetics, San Diego, CA
October, 2014
American Society of Human Genetics, San Diego, CA
September, 2014
Human Genome Variation, Belfast, Ireland
June, 2014
European Society of Human Genetics, Milan, Italy
June, 2014
European Society of Human Genetics, Milan, Italy
May, 2014
Sequencing, Finishing, Analysis in the Future, Santa Fe, NM
May, 2014
Sequencing, Finishing, Analysis in the Future, Santa Fe, NM
February, 2014
Advances in Genome Biology and Technology, Marco Island, FL
January, 2014
Plant and Animal Genome Conference XVII, San Diego, CA
November, 2013
Precision Medicine: Personal Genomes & Pharmacogenomics, Cold Spring Harbor, NY
January, 2013
Plant and Animal Genome Conference XXI, San Diego, CA
November, 2012
American Society of Human Genetics, San Francisco, CA

Literature

white papers

This White Paper explains how NGS leaves half of patients with genetic disorders without a molecular diagnosis, because it fails to adequately analyze repetitive parts of the genome and large structural variation. Bionano Genome Mapping is able to detect all SV types with high sensitivity and specificity, and examples of cancer and genetic disease are shown.

white papers

This white paper explains how Bionano NGM can make any sequency assembly up to 100 times more contiguous by scaffolding sequence contigs, and more exact by correcting errors. The new two-enzyme hybrid scaffold pipeline introduced here improves both aspects. It creates functional genomes at a low cost, no matter what your sequencing strategy is.

white papers

This White Paper explains how NGS fails to adequately analyze repetitive parts of the genome and large structural variation. Bionano’s Next-Generation Mapping is able to detect all SV types with high sensitivity and specificity, and examples of biologically important large structural variants in plant and animal genomes are shown.

case studies

This Case Study demonstrates the power of combining 2 single molecule technologies to produce Gold-quality genomes. Those allow the discovery of substantial amount of structural variation unique to individuals and populations otherwise not accessed by other short-read technologies.

case studies

This Case Study highlights Scientists at the USDA and Cold Spring Harbor Laboratory who know that better breeding of maize to feed a growing population will depend on an accurate reference assembly. They tackled the previously intractable crop with a combination of PacBio® Sequencing and BioNano Genomics®genome maps, leading to the first-ever high-quality reference assembly.

case studies

Scientists at Rutgers University, Washington University, and Ibis Biosciences successfully deployed Next-Generation Mapping (NGM) technology from Bionano Genomics to help produce the first complete assembly for a fast-growing aquatic plant with biofuel potential. What emerged is a clear view into a genome undergoing drastic reduction and a tool to elucidate chromosome-scale dynamics.