Stratify samples easily
The ability to stratify patient samples based on mutational profile usually requires extensive bioinformatic data curation downstream of sequencing. In a hepatocellular carcinoma study, our built-in pipeline automatically provides enough information to distinguish samples with or without a replication stress signature, resulting from a Hepatitis B Virus insertion 9 kb upstream of the Cyclin E1 gene. With the development of innovative therapies such as PARP inhibitors, patient stratification based on accumulation of DNA damage is critical.
Péneau C, Imbeaud S, La Bella T, et al. Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma. Gut. 2022;71(3):616-626. doi: 10.1136/gutjnl-2020-323153.