Identify mutations without complex pipelines

Cancer samples often display a high number of structural rearrangements or changes and the limitation caused by the short-read length of NGS is particularly detrimental for correctly reconstructing these chained fusion events. In this patient-derived breast cancer cell line, a consensus map resulting from the alignment of dozens of molecules spanning the region allowed OGM to identify a succession of a translocation, deletions and an inversion missed by short-read and long read-sequencing.